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Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy

The release of Si(OH) 2 is demonstrated to occur steadily during the 4 days of our experiment ( Figure 5 ), and this is in agreement with previous studies, which claim that SiNPs are in equilibrium with the soluble forms of Si in aqueous solutions (Spitzmller et al., 2023)

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GI events (nausea, vomiting, diarrhea) were the dominant safety signal and occurred at rates higher than reported for Phase 2 retatrutide and higher than for comparable dual or mono-agonist trials